Purpose:Insulin is involved in carbohydrate metabolism and also it’s very important because it increases storage
of glycogen, synthesis of fatty acids, absorption of amino acid, synthesis of protein. Insulin is clinically useful when we evaluate fasting patients in hypoglycemia, classify and predict diabetes, assess the activity of β-cell, research insulin resistance. We are going to increase usability of insulin assay by establishing normal reference value according to statistical analysis.
Materials & Methods: We selected 6,648 patients who visited asan health medical center from May to August in 2008. We set exclusion criteria as family of diabetes, diabetes medication, the past history of blood glucose rise, more than 100 mg/dL in normal fasting blood glucose, outside the scope of BMI 18.5~22.9 kg/m2, and more than HbA1c 6.5%. We determine whether the subgroup is portioned as sex and age or not and establish normal reference value by conducting statistical analysis as Bayesian’s method and Hoffman’s method.
Results:Portioning of subgroup as sex and age is not needed. By statistical analysis of Bayesian method, results 1.5?11.0 uIU/mL. By statistical analysis of Hoffman method, results 1.8~12.8 uIU/mL.
Conclusion:We established 1.8~12.8 uIU/mL as Insulin normal reference value by Hoffman method. This is a similar value with reporting reference value 1.7~11.8 uIU/mL in kit. This will enhance the usability of insulin assay by establishing normal reference value.
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